Multiplication of an attenuated RV11 strain (type SAT12) of foot-and-mouth disease virus in sheep.

نویسنده

  • P G Howell
چکیده

Investigations at Pirbright have shown that strains of virus which a re attenuated and immunogenic for cattle were also attenuated for sheep and produced a good immune response (Report, 1964). The work of Geering & Pay (1963) included studies with the RV11 vaccine strain, which at a high dosage level caused no post vaccinal reactions in a group of twenty four-month old lambs. Examination of the blood and saliva of ten of these lambs during the first week after vaccination, revealed a viraemia in six, while in four of them the saliva was a lso infective. The neutralizing antibody titres were higher than in cattle. In a preliminary report by Burrows, Geering, Mowat & Skinner (1963) it was shown that sheep which had been immunized with three dosage levels of a modified strain 119 mo C type A12 vaccine, developed, neutralizing antibodies within six to thirteen days after vaccination, even when the infectivity of the vaccine was reduced 1,000-fold.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Developing Vaccines against Foot-and-Mouth Disease: a Biotechnological Approach

Foot-and-mouth disease (FMD) is a contagious viral disease of livestock with significant economic effect. It is prevalent in various regions of Asia, Africa, and South America. The causative agent of this disease is called foot-and-mouth disease virus (FMDV), which is a member of Aphthovirus genus. Vaccination is an effective technique to prevent the complications of FMD and to eradicate the di...

متن کامل

An uncommon clinical form of foot-and-mouth disease in beef cattle presented with cornual skin lesions

Foot-and-mouth disease (FMD) is a major infectious disease in livestock. The common clinical signs in cattle include epidermal vesicles that are majorly distributed around oronasal cavity, feet and teats. The aim of this report is to document an uncommon clinical form of the disease which comprises the occurrence of classic vesicular lesion in a rarely observed location of the horn vegetative t...

متن کامل

Development of an Indirect Enzyme-linked Immunosorbent Assay to Detect Antibodies against Serotype A2013 of Foot and Mouth Disease Virus in Cattle

Foot and mouth disease (FMD) is a contagious animal disease that causes irreparable damage to the economy of countries, including Iran in which this disease is a native one. Among the ways to combat FMD are vaccination and slaughter. Due to the specific situation of Iran, it is not possible to kill infected animals. Therefore, vaccination is the most important way to fight this disease. S...

متن کامل

Assessment of Foot and Mouth Virus Subtype O2016 Genetic Alterations During Successive Passages in BHK Monolayer

Abstract : Foot and Mouth Disease is one of  the important live stocks contagious viral disease caused by Aphtovirus genus ,  that is belong to family RNA virus  picornaviride. The important characteristic of FMD virus is high mutation that give rise to diversity of Antigen in surface of Neutralizing proteins. For this reason FMD virus have 7 distinct serotype and many subtype. Vaccination is o...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Onderstepoort journal of veterinary research

دوره 33 1  شماره 

صفحات  -

تاریخ انتشار 1966